Formål
?
Polychlorinated compounds (PCBs) are biopersistant industrial toxicants. It has been discovered that billions of citizens worldwide are high-level exposed to semi-volatile PCBs evaporating from building materials. While numerous studies address health risk in relation to consumption of PCB contaminated food, the evidence on risk related to environmental airborne exposure to PCB is almost non-existent. The latter primarily involve non-dioxin like PCBs with unknown health effects in humans. The present project addresses health effects of PCBs in the indoor environment. The overall objective is to unravel whether inhalation of semi volatile PCB residues from building materials at the residence is associated with risk to human reproduction in terms of male reproductive function in young adulthood.
Indhold
?
Data contains measurements of PCB concentrations in the indoor air from selected apartments in Brøndby Strand and Farum Midtpunkt. There are both measurements of individual congeners and calculated sum measurements. In addition, data on 5152 men whose biological mothers were registered at the relevant addresses prior to birth. There are move-in and move-out data on the mothers and the men themselves. There are clinical and questionnaire data on 185 men who completed the study. Questionnaire data consider health and behavioral information incl. reportings on mother's smoking during pregnancy . The clinical examination includes anthropometric measurements as well as information on testicular size. In addition, we have data on sperm quality characteristics and reproductive hormones measured in blood. Data is linked to the national patient registers, but this data is not found outside Statistics Denmark and therefore cannot be uploaded.
Overall, we have data from three sources:
1. Sundhedsdatastyrelsen:
t_person_raw.dta: encrypted cpr, birth date, status, and status date for 5152 men and encypted cpr for their 3984 mothers Adressetabel_soen_raw.dta, Adressetabel_mor_raw.dta: relocation dates and specific adresses for son and mother, respectively aktuel_adresse: a key between encyrpted cpr and unencrypted cpr including current address for the 1431 of 1476 men identified as eligible due to prenatal exposure or control (see do-file "son_PCB_exposure N=5152.do"). The list was provided by Sundhedsdatastyrelsen after we provided them a list of those we were interested in contacting (by e-boks or regular postal service).
2. Statens Byggeforskningsinstitut, and GOLDER A/S:
PCB_Broendby, PCB_Farum: air measurements from Broendby Strand Parkerne and Farum Midtpunkt. Three datasets are available: by block (PCB_Brondby_B_blok.dta), by contamination status (PCB_Brondby_B_eks.dta) and by house number (PCB_Brondby_v_husnum). Same extensions are used for Farum meaurement data.
3. Redcap - questionnaire and clinical examination
Redcap_son: contains key between v_pnr_enc, lab_nr and record_id, all questionnaire responses (sociodemographic and health behavioral data) as well as clinically generated data including semen quality characteristics, blood pressure, anthropometry and spirometry for the 926 eligible exposed and controls (after matching 1:2). Questionnaire data was captured directly into redcap via electronic questionnaire. Clinical data was entered manually by a PhD student and a research assistant. Data was exported (raw file HESPERUSBIO_STATA_2020-02-06_1327.do) and cleaned (RedCap_son_housekeeping.do).
Full dataset - all variables Using the above files we generated a dataset with all available exposure, questionnaire and clinical data for the entire sourcepopulation (N=5151) including markers of whether they conformed with inclusion criteria (fetal_exp), if they were invited following matching and removal of unreachables (invited), and if they ented up completing enrolment (klin_und_complete). This full data set "Son_Exp_Ques_Clin_N=5152.dta" was sent to Denmark’s Statistics for further linckage to socioeconomic data and the National Patients Register.